DOS games didn’t have virtualised memory, while modern operating systems do. This may cause problems like “data execution” errors, where the DOS game tries to do things which aren’t allowed anymore. Even Win95 games may not run native on modern windows for this same reason.
But getting closer to your question…
You may also have trouble with sound on modern hardware. In the 1990s, sound cards used to be configured at Port 220h / IRQ 5or7 / DMA 0or1, with little deviation possible.
Since the early 2000s, sound hardware has been done differently (modern HDAudio standard vs old AC97 standard), and I’m not sure these old configurations can work anymore.
Installing a virtual sound driver may be possible, to remap the ports on your modern hardware to something your DOS games recognise, but don’t expect success.
If your hardware has a free PCI slot, you may be able to install an era-correct sound card, but I cannot guarantee this would work either.
