I know I’m late to the conversation, but I started by sitting down and reading the entire manual. It was a commitment, but I at least had the concepts of the game floating somewhere in my mind so when something came up, I knew there was at least something I could do about it. This did help me quite a bit in my first run through.
In full honesty though, this is the first 4X/Civilization like game I have ever played. So what I thought was user-unfriendly at first, may just be how these types of games play…