Pandora Directive worked great for me via PCem/86box (86box gets more updated recently).
Although, that was thru a Win98se install. It’s possible to do a native DOS install on ’em, but I don’t normally play games prior to ’93 so a DOS box (or restarting into DOS mode) in Win98 typically works for me.
I had a friend ask me about it recently and I zipped up my 86box install/setup into a 1.2gb download. No formatting or installing required, just extract and run (and of course, obtain the game’s iso from elsewhere). Let me know if this is a route anyone’s interested in, especially cuz it could be useful for other games too.